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Canine Patients Treated with Ocata’s Hemangio-derived Mesenchymal Cells (HMC™) Achieve Remission in a Model of Crohn’s Disease
reported in Regenerative Medicine that it has successfully used its proprietary hemangio-derived mesenchymal cell (HMCTM) technology to treat dogs with canine anal furunculosis (CAF), which shares many features with Crohn’s disease.
“This study provides the first evidence of the safety and therapeutic potential of human pluripotent stem cell-derived mesenchymal stem cells in a large animal model,” said Robert Lanza, M.D., Chief Scientific Officer of Ocata. “Canines have a physiology and sophisticated immune system that closely resembles that of humans, and canines are the only species that naturally develop symptoms and pathology similar to human fistulizing Crohn’s disease, including recurrent fistula activity, a difficult-to-treat manifestation of this chronic inflammatory bowel disorder. We treated six canines that were refractory to standard treatment, including cyclosporine therapy, and all of the canines were found to be completely free of fistulas at three months post-injection.”
“Ocata has developed a mesenchymal stem cell population from its proprietary hESC-derived hemangioblasts called HMCs, which are a self-renewing source of starting material, capable of generating a significant supply of minimally expanded cells with potent immunomodulatory and therapeutic properties,” said Paul K. Wotton, President and CEO who added “This successful study, along with other work we have conducted, provides a unique platform that can potentially be used to target significant autoimmune related disorders with high unmet needs such as Crohn’s disease and Lupus Nephritis.”
http://ir.ocata.com/press-releases/detail/2797
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