WVE
Viendo publicaciones sobre ASOs y la tecnología de WVE, veo cosas que no me cuadran, sobre todo teniendo en cuenta como han hecho la preclinica:
"Compounds that had nine or more Sp-linkages in the gap were found to be poorly active in vitro, while compounds with uniform Rp-gaps exhibited activity very similar to that of the stereo-random parent ASOs. Conversely, when tested in vivo, the full Rp-gap compound was found to be quickly metabolized resulting in low activity"
He visto en twitter varios coments sobre ello también