#121977
Re: Farmas USA
Gilead's remdesivir successful in late-stage COVID-19 study
Apr. 29, 2020 8:48 AM ET|About: Gilead Sciences, Inc. (GILD)|By: Douglas W. House, SA News Editor
Gilead Sciences (NASDAQ:GILD) announces positive results from an open-label Phase 3 clinical trial, SIMPLE, evaluating five- and 10-day courses of antiviral remdesivir in severely ill hospitalized COVID-19 patients
--Efficacy was similar between the two courses with no new safety signals observed.
--The time to clinical improvement for half the patients in the five-day arm was 10 days and 11 days in the 10-day group. 60% (n=120/200) of the patients in the five-day cohort were discharged from the hospital by day 14 while 64.5% (n=129/200) experienced clinical recovery by day 14. 52.3% (n=103/197) of the patients in the 10-day arm were discharged by day 14 and 53.8% (n=106/197)
achieved clinical recovery.
-- Clinical outcomes varied by geography. Outside of Italy, the mortality rate was 7.2% (n=23/320) across both treatment groups. 64.1% (n=205/320) of treated patients experienced clinical improvement by day 14 while 61.3% (n=196/320) were discharged from the hospital
--Efficacy was similar between the two courses with no new safety signals observed.
--The time to clinical improvement for half the patients in the five-day arm was 10 days and 11 days in the 10-day group. 60% (n=120/200) of the patients in the five-day cohort were discharged from the hospital by day 14 while 64.5% (n=129/200) experienced clinical recovery by day 14. 52.3% (n=103/197) of the patients in the 10-day arm were discharged by day 14 and 53.8% (n=106/197)
achieved clinical recovery.
-- Clinical outcomes varied by geography. Outside of Italy, the mortality rate was 7.2% (n=23/320) across both treatment groups. 64.1% (n=205/320) of treated patients experienced clinical improvement by day 14 while 61.3% (n=196/320) were discharged from the hospital