OCAT
Stem Cells Could Lead a Breakthrough in Curing Blindness
Es de otro estudio. Lo curioso es la visibilidad que le han dado a este por muchas partes. La opinión de los expertos sobre su inferioridad frente a OCAT:
This is using an extra-corporeal scaffold of RPE and that is placed in the eye (from what I cam gather). It is not a direct injection in the eye of RPE cells like OCATA. This technique may be more complicated and fraught with complications down the line.
We shall see if they are successful with this technique. But regardless of the outcomes they will be almost 5 years behind in safety data when compared to OCATA which is huge and that is not something that can be caught with regardless of how much money BP funds these studies.
On the surgical aspects of both approaches, someone at the posters admitted that the sheet approach is quite invasive compared to the injection approach.
There are instances where repositioning the retina, healthy retina, over a fresh bed of the underlying retina, can actually have improved sight. These instances are relatively uncommon, and typically the operation, which is highly invasive, can be complicated by side-effects of surgery, to the result of scarring and detachment of the retina. So, there are particular challenges associated with that surgery. …
this can't possibly be a treatment for dry AMD, nor is it certain that it will restore vision as opposed to an injection, nor is this a treatment and Ocata's just an experiment.
This one though contains quite a few subtle inaccuracies or dishonesties that may go unnoticed to the average reader, some examples:
A doctor in the UK has performed the world's first embryonic stem cell operation using a "patch" technique in the hope of finding a cure for blindness in some patients. -> Japan was first with a sheet.
In the new technique, a stem cell from an embryo is grown in the lab to create a single layer of retinal pigment epithelium cells. ->ACT was first with RPE cells.
"It's the combination of being able to create the cells that are missing and demonstrate that we can safely transplant them. ->They say it is first of all a safety study. Makes sense.
"This has the potential to be a treatment rather than being theoretical proof." ->And hope it may be used as a treatment. Makes sense.
A previous safety study published in The Lancet used stem cells in a solution but was not aimed at reversing sight loss or producing a therapy.
The goal of The Lancet was exactly the same as they're trying to do. Safety first, then efficacy. Why the lie?
And by the way, it didn't use "stem cells" in a solution, rather terminally differentiated cells, from blastomere-derived embryonic stem cells, rather than from the destroyed embryo's inner cell mass as I think they're doing.
http://www.emtv.com.pg/article.aspx?slug=Stem-Cells-Could-Lead-a-Breakthrough-in-Curing-Blindness-&subcategory=Top-Stories
UK doctor performs world's first embryonic stem cell operation aimed at curing blindness in people with an aged-related disease
http://article.wn.com/view/2015/09/28/UK_doctor_performs_worlds_first_embryonic_stem_cell_operatio/
Doctors take 'big step' towards a cure for age-related blindness
http://www.telegraph.co.uk/news/health/news/11896593/Doctors-take-big-step-towards-a-cure-for-age-related-blindness.html
First UK patient receives stem cell treatment to cure loss of vision
http://www.theguardian.com/science/2015/sep/29/first-uk-patient-receives-stem-cell-treatment-to-cure-sight-loss
«Después de nada, o después de todo/ supe que todo no era más que nada.»