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Farmas USA

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Farmas USA
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#101737

Re: Farmas USA

ARNA

 

positive Phase 2 results for ralinepag, an investigational, long-acting, orally administered prostacyclin receptor agonist under development for the treatment of pulmonary arterial hypertension (PAH).  In this 61-patient study, the primary efficacy analysis demonstrated a statistically significant absolute change from baseline in pulmonary vascular resistance (PVR) compared to placebo.  Ralinepag also demonstrated numerical improvement in 6-minute walk distance (6MWD).

Ralinepag improved median PVR by 163.9 dyn.s.cm-5 from baseline compared to a 0.7 dyn.s.cm-5 worsening from baseline in the placebo arm (P=0.02).  Patients treated with ralinepag had a 29.8% improvement in PVR compared to the placebo arm (P=0.03) and a 20.1% improvement in PVR compared to baseline. Additionally, adverse events observed in the study were consistent with other prostacyclin treatments for the management of PAH, with headache, nausea, diarrhea, jaw pain and flushing being the most commonly reported adverse events. The company plans to present full study results at future medical congresses.

"The positive outcome of this Phase 2 trial in a contemporary PAH patient population is an important milestone in the development of ralinepag for the treatment of patients suffering from this grievous illness," stated Preston Klassen, M.D., MHS, Executive Vice President, Research and Development and Chief Medical Officer of Arena.  "It is exciting to see the positive nonclinical pharmacological profile translating into potentially the first oral prostacyclin therapy that may approach consistent therapeutic levels without the complexity of parenteral (IV) therapy.  These data give us confidence to move expeditiously toward a Phase 3 clinical program."

Vallerie McLaughlin, M.D., Kim A. Eagle MD Endowed Professor of Cardiovascular Medicine at the University of Michigan and Director of the Pulmonary Hypertension Program, added, "PAH is a complex and serious disease, often with a poor prognosis despite the use of currently available treatments. New therapeutic options to manage patients with PAH are needed. The results of this Phase 2 study of ralinepag, in patients already receiving, in most cases, multiple background therapies, showed a clinically meaningful improvement in PVR, a well-established indicator of treatment benefit, believed to be correlated with long-term clinical outcomes in patients with PAH."

«Después de nada, o después de todo/ supe que todo no era más que nada.»

#101738

Re: Farmas USA

VTGN
Con la tontería x10 volumen y +6%. Lo cierto es que han escrito muchísimos tweets XD. Además insider buying.

ACHN
Dimite el CSO, creo que ha durado año y medio...

#101739

Re: Farmas USA

ARNA

algo iban a sacar de resultados pero vamos, que me tire un año y lo maximo que las vi fue 1,90 y algo... y eso equivaldria a 19 de ahora. Si luego me bajo a 1,25 que fue cuando le di por culo... pues a ver cuando explota. Aunque va a hacer un sarepta, subir y subir para no bajar, otra que pude entrar y no me meti, en esa por lo menos no perdi, jeje

#101740

Re: Farmas USA

DEPO

 

Estoy desconectada, pero  he visto volumen al final de sesión y están a buen precio. Valdría la pena tirarles unas líneas

«Después de nada, o después de todo/ supe que todo no era más que nada.»

#101741

Re: Farmas USA

ARNA

26.11   41.98% madre mia.... y tiene volumen, esta mañana que llega a 40? xDDD