Erdys, esto es de hoy, si no me equivoco...
¿Qué es lo que esperas para mañana en cuanto a TGTX?
12:12 am TG Therapeutics announced interim data from phase 1 dose escalation clinical trial of TGR-1202, the Once-Daily PI3K delta inhibitor, demonstrates significant clinical activity and lack of hepatic toxicity in patients with relapsed/refractory chronic lymphocytic leukemia and non-hodgkin's lymphoma (TGTX) : Co announced interim data from phase 1 dose escalation clinical trial of TGR-1202, the Once-Daily PI3K delta inhibitor, demonstrates significant clinical activity and lack of hepatic toxicity in patients with relapsed/refractory chronic lymphocytic leukemia and non-hodgkin's lymphoma
93% (13/14) of evaluable CLL patients treated at dose levels A 800mg of original formulation or any dose of the micronized formulation achieved a > 50% reduction in nodal size (a nodal PR) and 50% (7/14) achieved a partial response per iwCLL (Hallek 2008) criteria
100% (6/6) of CLL and iNHL patients achieving TGR-1202 drug concentrations above 4,000ng/ml responded at the first or second efficacy assessment with at least a nodal PR for CLL or PR for iNHL; Expansion cohorts now open at 800mg QD for CLL and 1200mg QD for iNHL, the dose level that appears to provide patients (3/3) with drug concentrations > 4,000ng/ml
No drug related hepatic toxicity or colitis observed with 55 patients treated to date and median time on study of approximately 6 months and some patients on study for over 1.5 years