De momento, mantengo las PPHM...
Falta la conferencia de hoy.....
Las IDRA, también las sigo mateniendo, al igual que las CTIX y las jodidas THLD....
Salen las BLRX, por cansinas y aburridas, y entran las IMMU, a ver si tras el meneo de ayer se deciden a subir....
Immunomedics (NASDAQ: IMMU) announced that, in a mid-stage clinical study, a multitude of patients with late stage solid cancers showed significant and durable tumor shrinkage after receiving treatments with sacituzumab govitecan, the Company's lead antibody-directed chemotherapeutic agent in development. These include patients with metastatic triple-negative breast cancer whose cancers after treatment were no longer detected by computed tomography, a test commonly used to find and locate tumors, and to measure a patient's treatment response.
"All of these patients had failed many prior therapies for their cancers and were running out of options before being treated with sacituzumab govitecan," stated Dr. Alexander N. Starodub of the Indiana Health Center for Cancer Care, Goshen, Indiana, one of the Principal Investigators. "In this respect, we are very encouraged with the responses we are reporting at this year's Annual Meeting of the American Association for Cancer Research, especially in light of the fact that this novel agent is given to patients as a monotherapy, and not part of a drug cocktail. I believe sacituzumab govitecan has the potential to become a viable alternative for treating patients with advanced, metastatic solid cancers if these results are confirmed in a late-stage clinical trial," added Dr. Starodub.
At the time of analysis, a total of 184 patients with many different advanced, metastatic cancers were enrolled into the study. Dr. Starodub's oral presentation focused on interim responses from 130 patients having these four major solid cancer types: breast, lung, esophageal, and colorectal.
For patients with triple-negative breast cancer, 26% showed objective response to sacituzumab govitecan, with 2 having a complete disappearance of their tumors, or complete response, and 10 showing a 30% or better tumor reduction, which qualified them as partial responders in accordance with the rules set by the Response Evaluation Criteria In Solid Tumors (RECIST 1.1). Including patients with responses between less than 30% tumor shrinkage and less than 20% tumor increase, which are considered stable disease, the disease control rate was 74%. At present, 21 of these patients are continuing therapy.
Cancer Types (N*) Objective Response** Disease Control
Triple-Negative Breast (46) (2+10) (26%) 34 (74%)
Non-Small Cell Lung (19) 6 (32%) 14 (74%)
Small Cell Lung (20) 6 (30%) 11 (55%)
Esophageal (16) 2 (13%) 9 (56%)
* N represents the number of patients that are evaluable at this time for treatment response.
** Except with triple-negative breast cancer (2 patients with complete response), all objective responses are partial responses.
In lung cancer, the objective response rates were 32% and 30% for non-small-cell and small-cell lung cancers, respectively, and disease control rates were 74% and 55%, respectively. "These results compare very favorably to all other agents used in this disease and setting," commented Dr. Starodub. For the 18 patients with advanced cancer of the esophagus enrolled into the study, 16 were assessable for response, having an objective response rate of 13% and a disease control rate of 44%.
Also reported were results on 29 patients with colorectal cancer in early assessments of survival. The median length of time living without the disease getting worse from the beginning of their sacituzumab govitecan treatments was 3.9 months. The median length of survival from the start of treatment was 18.0 months. "These are very encouraging preliminary results for patients who had a median of 4 prior therapies for metastatic colorectal cancer, some as many as 8," remarked Dr. Starodub.
