Novavax NanoFlu™ Vaccine Demonstrates Improved Immune Responses Compared to Egg-Based, High-Dose Flu Vaccine
- Phase 2 trial of NanoFlu vaccine expected to begin in third quarter of 2018
- Given strength of trial data, Novavax has submitted detailed results for publication in peer-reviewed medical journal
- Company management to discuss more complete trial results after publication
GAITHERSBURG, Md., February 28, 2018 -- Novavax, Inc., (Nasdaq:NVAX) today announced positive top-line results from its Phase 1/2 clinical trial in older adults of its NanoFlu recombinant influenza vaccine, which includes its proprietary Matrix-M™ adjuvant, compared to the leading licensed egg-based, high-dose influenza vaccine for older adults (IIV3-HD).
Key findings from the trial include that Nanoflu vaccine induced:
- Significantly higher hemagglutination inhibition (HAI) antibody responses against homologous H1N1 and H3N2 strains and comparable HAI responses against the homologous B/Brisbane strain,
- Significantly higher HAI immune responses against historic and forward-drifted H3N2 strains, and
- Strong neutralizing antibody responses that correlate with HAI results against H3N2 strains.
H3N2 has been a consistent public health challenge and is associated with roughly 75% of this season’s flu-related hospitalizations.1 Against three tested H3N2 strains, the ratio of day 21 HAI geometric mean titers (GMTs) show significant responses of NanoFlu vaccine over IIV3-HD:
http://ir.novavax.com/news-releases/news-release-details/novavax-nanoflutm-vaccine-demonstrates-improved-immune-responses