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Grifols (GRF): siguiendo de cerca la acción

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#1345

Re: Grifols (GRF): siguiendo de cerca la acción

Aquí está la publicación completa:

https://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1002/alz.12137

Pego el resumen. 

This phase 2b/3 trial examined the effects of plasma exchange (PE) in patients with mild‐to‐moderate Alzheimer's disease (AD).

Methods


Three hundred forty‐seven patients (496 screened) were randomized (1:1:1:1) into three PE treatment arms with different doses of albumin and intravenous immunoglobulin replacement (6‐week period of weekly conventional PE followed by a 12‐month period of monthly low‐volume PE), and placebo (sham).

Results


PE‐treated patients performed significantly better than placebo for the co‐primary endpoints: change from baseline of Alzheimer's Disease Cooperative Study–Activities of Daily Living (ADCS‐ADL; P  = .03; 52% less decline) with a trend for Alzheimer's Disease Assessment Scale–Cognitive Subscale (ADAS‐Cog; P  = .06; 66% less decline) scores at month 14. Moderate‐AD patients (baseline Mini‐Mental State Examination [MMSE] 18‐21) scored better on ADCS‐ADL (P  = .002) and ADAS‐Cog (P  = .05), 61% less decline both. There were no changes in mild‐AD patients (MMSE 22‐26). PE‐treated patients scored better on the Clinical Dementia Rating Sum of Boxes (CDR‐sb) (P  = .002; 71% less decline) and Alzheimer's Disease Cooperative Study‐Clinical Global Impression of Change (ADCS‐CGIC) (P  < .0001; 100% less decline) scales.

Discussion


This trial suggests that PE with albumin replacement could slow cognitive and functional decline in AD, although further studies are warranted.

«Después de nada, o después de todo/ supe que todo no era más que nada.»

#1346

Re: Grifols (GRF): siguiendo de cerca la acción

Estoy metido en el sector biosanitario del Alzheimer y no me he metido en Grifols por esto. De hecho siempre me ha parecido un poco "salvaje" este recambio plasmático completo.

"Lo que todo el mundo sabe en la Bolsa a mí ya no me interesa" André Kostolany

#1347

Re: Grifols (GRF): siguiendo de cerca la acción

Y me pregunto yo (que estoy acostumbrada a las farmas americanas): ¿No hay sell-the-news aquí? ¿Podría alguien comentar su comportamiento habitual frente a noticias y previo a resultados trimestrales?

Me acabo de leer el artículo completo. Mi lectura de ensayos clínicos es de nivel de trabajo, me falta un punto médico y otro estadístico. Dicho eso, los resultados son buenos en la disminución de la progresión de la enfermedad de Alzhéimer, pero creo ver cierto minado de datos: ahora creo un grupo leve y otro moderado; uso varias escalas y luego escojo la que me conviene. 

Y luego lo veo un procedimiento costoso y de difícil aplicación para algo que no es una cura. Se agradecerán visiones más especializadas.

«Después de nada, o después de todo/ supe que todo no era más que nada.»

#1348

Re: Grifols (GRF): siguiendo de cerca la acción

Hombre, yo creo que no es la cura soñada para el Alzheimer, hacerle pasar a un individuo 1 vez a la semana por una reposición completa de su sangre. 

"Lo que todo el mundo sabe en la Bolsa a mí ya no me interesa" André Kostolany

#1349

Re: Grifols (GRF): siguiendo de cerca la acción

Semanales son durante mes y medio, luego pasan a ser mensuales. Pero sí, a eso me refería yo con "complicado y costoso".

«Después de nada, o después de todo/ supe que todo no era más que nada.»

#1351

Re: Grifols (GRF): siguiendo de cerca la acción

Pues hoy va bastante bien la acción. No se si es por la inmoglobulina, por AMBAR o es que los resultados vienen buenos.

Grifols es líder mundial en su sector. De lo poco que se salva de España. Y no lo digo yo. Lo dicen las propias filtraciones de wikileaks donde los yankees reconocían a Grifols como de interés estratégico.

Si la inmoglobulina es eficaz de verdad, tendrá mercado en EEUU por muchos miles de $ que cueste el tratamiento. A veces se nos olvida el nivel de vida que tienen en norteamérica. La renta de un trabajador normal en España sería considerada como pobre de solemnidad allá.






#1352

Re: Grifols (GRF): siguiendo de cerca la acción

Asignación de fondos europeos para plasma anti Covid-19


BRUSSELS, July 29 (Reuters) - The European Union has made
available up to 45 million euros ($53 million) to increase the
collection of plasma from COVID-19 survivors for the treatment
of people who contract the disease, a spokesman told Reuters.
    The move confirms the EU's growing confidence in
experimental therapies based on so-called convalescent plasma,
which is currently used in hospitals for direct transfusions to
critically ill patients and is being tested to develop possible
medicines against COVID-19 [nL8N2EF56U].  
    Money is coming from an emergency fund that the European
Union has so far used only for highly sensitive issues
throughout the pandemic, including the purchase of another
COVID-19 treatment and potential vaccines.
    Grants will be distributed to blood collection centres to
help them buy new equipment, such as testing kits and machines
that separate plasma from blood, the EU spokesman said.
    Collection centres run by private companies could also
access the funding, an EU official said. 
    Spain's Grifols <GRLS.MC> and a corporate alliance led by
Japanese drugmaker Takeda <4502.T> have collected convalescent
plasma to develop a medicine against COVID-19.
    The Takeda-led alliance, which also includes Biotest AG
<BIOG.DE>, CSL Behring and Octapharma Plasma, said earlier it
was set to delay the launch of clinical trials on its
plasma-based drug which were due to begin in July because of
regulatory issues [nL3N2F02GB].
    The European Commission's spokesman said the money made
available to help the collection of plasma could also be used to
cover costs to retool drugs against COVID-19.
    But "it is expected that a large part of the available
funding will be used for plasma", the spokesman said.
    The EU sealed in July supply deals with Roche for its
arthritis drug RoActemra and with Merck for its multiple
sclerosis drug Rebif, which were both being retooled to treat
COVID-19 patients alone or in combination with other drugs
[nL8N2EF2N8].
    The Commission declined to clarify on Wednesday whether
funds were made available to Roche and Merck to repurpose their
drugs or whether the supply deal with Roche was still valid
after RoActemra failed its COVID-19 trial earlier on Wednesday
[nL5N2F010O]
    Money for plasma comes from an EU emergency fund which the
Commission said on Wednesday deployed 63 million euros to buy
remdesivir, the only drug at this stage authorised in the bloc
against COVID-19 [nL5N2F03VU].
    The bloc has also committed about 2 billion euros of the
rainy-day fund to secure advance purchase deals of potential
vaccines against the disease, EU officials told Reuters. 
    ($1 = 0.8524 euros)



«Después de nada, o después de todo/ supe que todo no era más que nada.»